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Health Sciences Authority

Publications and Presentations

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2014

  • “Structural elucidation of propoxyphenyl isobutyl aildenafil, adulterant in a health supplement using high-resolution Orbitrap mass spectrometry”. Chee Leong Kee, Hwee Ling Koh, Bosco Chen Bloodworth, Yun Zeng, Kin Har Kiang, Min Yong Low and Xiaowei Ge. Journal of Pharmaceutical and Biomedical Analysis, Vol 98, 2014, p 153-159.
  • “Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: Analytical techniques and challenges”. Dhavalkumar Narendrabhai Patel, Lin Li, Chee Leong Kee, Xiaowei Ge, Min Yong Low and Hwee Ling Koh. Journal of Pharmaceutical and Biomedical Analysis, Vol 87, 2014, p 176-190.
  • “Screening for weight loss drugs in herbal products by liquid chromatography-coupled quadrupole tandem mass spectrometry”. Lan Eng Low, Yun Zeng, Chee Leong Kee, Xiaowei Ge and Min Yong Low. Poster presentation at the Drug Analysis 2014, Liege, Belgium, 23-25 Jun 2014.
  • “Identification of acrylamide in cosmetic products by liquid chromatography – tandem mass spectrometry”. Jia Yi Kwang. Poster presentation at the 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, Maryland, USA, 15-19 Jun 2014.
  • “Updates on PDE-5 inhibitor analogues, sharing on Hans Skin care case, OxyELITE and Herbal Health Jointcare samples”. Xiaowei Ge. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, Utrecht, The Netherlands, 26-30 May 2014.
  • “Monograph Structure and Function”. Debbie Sun. Oral presentation at the Day Briefing on International Pharmacopoeia, Geneva, Switzerland, 2 Apr 2014.
  • “Validation of Analytical Chemical Methods for Testing and Measuring Cigarette Contents and Emissions”. Nuan Ping Cheah. Oral presentation at 8th Meeting of the Articles 9 & 10 of the WHO FCTC, The Netherlands, Jan 2014.

2013

  • “Structural elucidation of a new sildenafil analogue using high-resolution Orbitrap mass spectrometry”. Chee Leong Kee, Xiaowei Ge, Min Yong Low and Hwee Ling Koh. Rapid Communications in Mass Spectrometry, Vol 27, 2013, p 1380-1384.
  • “Isolation and structural elucidation of a new sildenafil analogue from a functional coffee”. Lin Li, Min Yong Low, Xiaowei Ge, Bosco Chen Bloodworth and Hwee Ling Koh. Analytical and Bioanalytical Chemistry, Vol 405, 2013, p 4443-4450.
  • “In vitro effects of aldehydes present in tobacco smoke on gene expression in human long alveola epithelial cells”. Nuan Ping Cheah, Jeroen L.A. Pennings, Jolanda P. Vermeulen, Frederik J. van Schooten and Antoon Opperhuizen. Toxicology in Vitro, Vol 27, 2013, p 1072-1081.
  • “Separation of Methoxsalen and its isomers in Chinese Proprietary Medicines using Core-Shell HPLC Column and ESI-LC-MS/MS”. Chee Leong Kee, Cuilian Sun, Xiaowei Ge and Min Yong Low. Poster presentation at the 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Tasmania, Australia, 18-21 Nov 2013.
  • “Establishing an Ultra-High Performance Liquid Chromatography Method for Screening of Western Drug Adulterants in Complementary Health Products”. Yi Ling Quek, Gay Khng Teo, Elbert Wijaya and Min Yong Low. Poster presentation at the Euroanalysis XVII European Conference on Analytical Chemistry, Warsaw, Poland, 25-29 Aug 2013.
  • “Screening and evaluation of adulterants in 247 illegal sexual performance enhancement products using HPLC-DAD and GC-MS”. Yimin Xu, Min Yong Low, Yun Zeng, Lin Li, Xiaowei Ge, Ruth Lee, Bosco Chen Bloodworth and Hwee Ling Koh. Poster presentation at the 39th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Amsterdam, Netherlands, 16-20 Jun 2013.
  • “Screening of Multiple Oxidative Hair Dyes by High Performance Liquid Chromatography”. Kin Har Kiang, Jia Yi Kwang, Chai Rou Lin and Nuan Ping Cheah. Poster presentation at the 39th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Amsterdam, Netherlands, 16-20 Jun 2013.
  • “Aconite alkaloids in Yunnan Baiyao, ADR cases associated with plant’ inherent toxicity, Progesterone in traditional supplements containing Commiphora mukul  (Oleogum resin, guggul)”. Xiaowei Ge. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, Santander, Spain, May 2013.
  • “A study on the conversion of methanol to formaldehyde in the GC injection port and reactivity with amines”. Chee Leong Kee. Poster presentation at the 37th International Symposium on Capillary Chromatography and the 10th GCxGC Symposium, Palm Springs, California, USA, 12-16 May 2013.
  • “An Emerging Threat: Adulteration of Complementary Health Products with Western Drugs and Their Analogues”. Chee Leong Kee. Oral presentation at the National Pharmacy Enforcement Conference, Ministry of Health Malaysia, Penang, Malaysia, 23-26 Apr 2013.

2012

  • “Partial conversion of methanol to formaldehyde in the gas chromatography injection port and reactivity with amines”. Chee Leong Kee, Chian Sing Lai, Xiaowei Ge, Min Yong Low and Laura A. Ciolino. Journal of Chromatography A, Vol 1257, 2012, p 158-170.
  • “Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements”. Chee Leong Kee, Xiaowei Ge, Hwee Ling Koh and Min Yong Low. Journal of Pharmaceutical and Biomedical Analysis, Vol 70, 2012, p 265-272.
  • “Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement”. Min Yong Low, Lin Li, Xiaowei Ge, Chee Leong Kee and Hwee Ling Koh. Journal of Pharmaceutical and Biomedical Analysis, Vol 57, 2012, p 104-108.
  • “Adverse events associated with the use of complementary medicine and health supplements: an analysis of reports in the Singapore Pharmacovigilance database from 1998 to 2009”. Dhavalkumar Narendrabhai Patel, Wai Ling Low, Libel Liesebet Tan, Mui Mui Belinda Tan, Qian Zhang, Min Yong Low, Cheng Leng Chan and Hwee Ling Koh. Clinical Toxicology, Vol 50, 2012, p 481-489.
  • “Capsule shells adulterated with tadalafil”. Bastiaan J. Venhuis, Jing Tan, Marjo J. Vredenbregt, Xiaowei Ge, Min Yong Low and Dries de Kaste. Forensic Science International, Vol 214, 2012, p e20-e22.
  • “Electronic nicotine delivery systems: regulatory and safety challenges: Singapore perspective”. Nuan Ping Cheah, Norman Wee Lin Chong, Jing Tan, Faridatul Akmam Morsed and Shen Kuan Yee. Tobacco Control, 2012, doi:10.1136/tobaccocontrol-2012-050483.

2011

  • “Identification of a new sildenafil analogue in a health supplement”. Xiaowei Ge, Lin Li, Hwee Ling Koh and Min Yong Low. Journal of Pharmaceutical and Biomedical Analysis, Vol 56, 2011, p 491-496.
  • “Is methanol a good extraction solvent for use in adulterant screening by GCMS?”. Chee Leong Kee. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, Singapore, 17-21 Oct 2011.
  • “Overview of Adverse Drug Reaction (ADR) Cases Associated with Herbal Supplements, Screening of PDE-5 inhibitors and their analogues by Mass Spectrometry techniques”. Xiaowei Ge. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, Singapore, 17-21 Oct 2011.
  • “Yohimbine analogue found in a health supplement, Litchin Enzim case sharing, Black pill in Singapore”. Xiaowei Ge. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, London, UK, 13-16 Jun 2011.
  • “Determination of Benzo[a]Pyrene in Cigarette Mainstream Smoke”. Jing Tan. Oral presentation at the WHO Tobacco Laboratory Network (TobLabNet) Method Validation Working Group Meeting, Kiev, Ukraine, 3-6 May 2011.

2010

  • “Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product”. Adrian Häberli, Philippe Girard, Min Yong Low and Xiaowei Ge. Journal of Pharmaceutical and Biomedical Analysis, Vol 53, 2010, p 24-28.
  • “Adulterated heath products found in Singapore”. Xiaowei Ge. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, Montreal, Canada, Jun 2010.

2009

  • “Safety and Quality Assessment of 175 Illegal Sexual Enhancement Products Seized in Red-Light Districts in Singapore”. Min Yong Low, Yun Zeng, Lin Li, Xiaowei Ge, Ruth Lee, Bosco Chen Bloodworth and Hwee Ling Koh. Drug Safety, Vol 32, 2009, p 1141-1146.
  • “Isolation and structural elucidation of dapoxetine as an adulterant in a health supplement used for sexual performance enhancement”. Lin Li, Min Yong Low, Xiaowei Ge, Bosco Chen Bloodworth and Hwee Ling Koh. Journal of Pharmaceutical and Biomedical Analysis, Vol 50, 2009, p 724-72.
  • “Tadalafil detected in the capsule shell of a health supplement, Update of the new analogues detected in functional coffee and health supplements, Testing of illegal health products in Singapore”. Xiaowei Ge. Oral presentation at the International Laboratory Forum on Counterfeit Medicines, Bern Switzerland, Jun 2009.