21 Dec 2006: Oseltamivir (Tamiflu®) and neuropsychiatric events
			There are recent post-marketing reports of neuropsychiatric adverse events suspected to be associated with oseltamivir. These include events such as delirium with prominent behavioural disturbances and suicidal events including self-injury and suicidal ideation.

			21 Dec 2006: Eptifibatide (Integrilin®) and increased risk of bleeding in impaired renal function
			Recent literature reports suggest an increased risk of bleeding in patients with impaired renal function when administered infusion doses of eptifibatide similar to those in patients with normal renal function. A lower infusion dose of 1mcg/kg/min was to be considered for patients witj creatinine clearance between 30-50 ml/min when used for both acute coronary syndrome and percutaneous coronary intervention.

			21 Dec 2006: Life-threatening cases of serotonin syndrome with SSRI/SNRI-triptan combination
			Physicians are reminded about the potential risk of developing serotonin syndrome in patients taking 5-hydroxytryptamine receptor agonists (triptans) and Selective Serotonin Re-uptake Inhibitors (SSRIs) or Selective Norepinephrine Re-uptake Inhibitors (SNRIs).

			21 Dec 2006: Raloxifene (Evista®) and risk of venous thomboembolism / fatal stroke
			The results of the Raloxifene Use for the Heart (RUTH) Study raises safety concerns. They suggest that raloxifene did not demonstrate to protect women against heart disease and could be associated with excess deaths from stroke.

			21 Dec 2006: Presence of heavy metals in traditional Indian medicines – A case of lead poisoning with ayurvedic medicine, Endopile®
			Endopile® capsules (manufactured by Santhigiri Ayurveda and Siddha Vaidyasala) was found to contain excessive amount of lead. This product is indicated for the treatment of piles and related symptoms and labelled to contain herbal ingredients.

			11 Dec 2006: Warning against taking "Santi Bovine Penis Erecting Capsules"
			The Health Sciences Authority (HSA) warns members of the public not to consume an illegal product labelled as "Santi Bovine Penis Erecting Capsules", which has been found to contain a drug called "sildenafil".

			26 Jul 2006: Angiotensin-converting enzymes (ACE) inhibitors exposure in 1st trimester & congenital malformations
			New study suggests that congenital malformations may be associated with ACE inhibitors exposure in early pregnancy.

			26 Jul 2006: Safety update on anti-tumour necrosis factor alpha (anti-TNFα) products
			Hepatitis B reactivation have been reported in patients receiving anti-TNFα products such as etanercept (Enbrel®), adalimumab (Humira®) or infliximab (Remicade®) therapy.

26 Jul 2006: Termination of Long-Term Intervention on Fractures with Tibolone (LIFT) Study

			26 Jul 2006: Reports of nephrogenic fibrosing dermopathy (NFD) & nephrogenic systemic fibrosis
			(NSF) following the use of gadolinium-containing agentsThere are 25 case reports of serious and unexpected reactions of nephrogenic fibrosing dermopathy (NFD) and nephrogenic systemic fibrosis (NSF) in association with the use of Omniscan®. Twenty of these were reported in Denmark and five in Austria. All patients who developed NSF/NFD had severely impaired renal function, with the majority receiving dialysis before Omniscan® was administered.

			26 Jul 2006: Potential risk of cutaneous vasculitis toxicities associated with hydroxyurea (Hydrea®)
			Reports of cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, have been reported with the use of hydroxyurea in patients with myeloproliferative disorders. These vasculitic toxicities were reported most often in patients with a history of, or concurrently receiving interferon therapy.

			26 Jul 2006: Case report of adverse reactions with Baike Wan®, Shen Loon She (SLS) 百科丸,清肝解毒泻火珍品,神农氏
			It was found to be adulterated with chlorpheniramine, frusemide and piroxicam. It is labelled to contain herbal ingredients and indicated for the relief of muscle and joint pain.

			26 Jul 2006: Black cohosh (Cimicifuga Racemosa) & hepatotoxicity
			There are reports of abnormal liver function, autoimmune hepatitis, massive and sub-massive necrosis suspected to be associated with the use of black cohosh. It is generally used to assist in the relief of the symptoms of menopause.

			5 Apr 2006: Safety update on gatifloxacin (Tequin®)
			Serious cases of both hypoglycaemia and hyperglycaemia have been reported with gatifloxacin during post-marketing surveillance.

			5 Apr 2006: Letrozole (Femara®) and adverse outcome in babies following maternal exposure
			Physicians are reminded about the association of letrozole and potential embryo- and fetotoxicity with or without teratogenicity, and use of letrozole is contraindicated in women with premenopausal endocrine status as well as pregnancy and lactation.

			5 Apr 2006: Bosentan (Tracleer®) and serious liver injury
			Patients on bosentan therapy should be closely monitored for elevations in serum aminotransferases.

			5 Apr 2006: Macular oedema associated with rosiglitazone (Avandia®)
			There are rare post-marketing reports of new onset and worsening macular oedema in patients receiving rosiglitazone. In the majority of these cases, the patients also reported concurrent peripheral oedema.