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Health Sciences Authority

FY 2014/15

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> Research Publications

> Research Projects

Research Publications

April 2014 to March 2015

Please click here to view more details of the Publications

Applied Services Group

Title of Paper


An Improved Reference Measurement Method for Hemoglobin A1c Using Liquid Chromatography Isotope Dilution Tandem Mass Spectrometry (LC‐IDMS/MS)

Lingkai Wong, Hong Liu, Sharon Yong, Qinde Liu, Tong Kooi Lee

Providing a traceable assigned value in a proficiency testing programme on the determination of benzoic acid in orange juice

Shiwan Cheng, Charline Mesquida, Ee Mei Gui, Pui Sze Cheow, Tong Kooi Lee, Tang Lin Teo

Determination of total thyroxine in human serum by hollow fiber liquid-phase microextraction and liquid chromatography–tandem mass spectrometry

Sharon Yong, Yizhao Chen, Tong Kooi Lee, Hian Kee Lee

Determination of Ochratoxin A in Capsicum spp. (Paprika and Chili) by Immunoaffinity Column Cleanup and Liquid Chromatography: Collaborative Study

E. Abilleira; P. Bastijns; M. Berger; G. Cepurnieks; S.J. Coluccia; J. Griffin; M-P. Herry; J.R. Keegan; P. Kormali; C.W. Lim; S. MacDonald; G. Muranszky; K. Nuotio; J. Postupolski; A. Solyakov; Staiger; M. Toome; E. Toth; J. Vancutsem; C. Veitch; C. Yustes

Quantitative assessment of Moniliformin in Cereals via alternative precipitation pathways, aided by targeted and untargeted mass spectrometry

Chee Wei Lim; Kit Yee Lai; Jie Fang Yeo; Siew Hoon Tai; Sheot Harn Chan

Verifying the provenance of rice using stable isotope ratio and multi-element analyses: a feasibility study

Angela Li, Joanne Chan, Simon Kelly

Isotope ratio analysis of carbon and nitrogen by elemental analyser continuous flow isotope ratio mass spectrometry (EA-CF-IRMS) without the use of a reference gas

L. J. Bay; S. H. Chan and T. Walczyk

Multi-Mycotoxin screening reveals separate occurrence of aflatoxins and ochratoxin A in Asian rice

Chee Wei Lim, Tomoya Yoshinari, Jeff Layne, Sheot Harn Chan

Structural elucidation of propoxyphenyl isobutyl aildenafil, adulterant in a health supplement using high-resolution Orbitrap mass spectrometry

Kee Chee Leong, Hwee Ling Koh, Bosco Chen Bloodworth, Zeng Yun, Kin Har Kiang, Min Yong Low, Xiaowei Ge

Hepatotoxic potential of asarones: In vitro evaluation of hepatotoxicity and quantitative determination in herbal

Dhavalkumar Narendrabha Patel, Han Kiat
Ho, Libei Liesbet Tan, Mui-Mui Belinda Tan, Qian Zhang, Min-Yong Low, Cheng-Leng Chan, Hwee-Ling Koh

Differentiation of Three Fluoroethcathinone Positional Isomers - A case study

Dr. Romelo Bandian Gibe, Ms. Wendy Lim Jong Lee, Dr. Angeline Yap Tiong Whei

History and current status of forensic science in Singapore

George Paul, Paul Chui

Blood Services Group

Title of Paper


Blood and Marrow Derived Non Hematopoietic Stem Cell Sources & Immune Cells for Clinical Application

Dr Mickey Koh

Transfusion Support for HLA Refractory Patients in Singapore

Alcantara R, Kyi Kyi S, Widanalage S, Chee YL, Poon M, Koh LP, Tan LK, Ho AYL and Ang AL

Optimising Donor Traffic on Weekends at the Bloodbank@Woodlands

Othman R, Ramli RMS and Rahamat NMS

Enhance the Efficiency of Processing Double Dose Apheresis Platelets

Saiman SN, Rahamat N, Chua SS, Su X, Begum S, Lim C, Ng KS and Oliveiro C

Minimizing Percentage of Fresh Frozen Plasma Discard Due to Breakages

Ciuputra H, Tan WC, Leong TS, Surasi S, Tan KL, Sangalang AG, Alcantara AGP and Shu Pei Huey

Massive Transfusion Protocol in Singapore – Our Experience in Introducing and Running A Common National MT Protocol (2011-2013)

Chay JWM, Koh MBC, Tan HH, Ng HJ, Ng JCF, Chua CML, Chia NCH, Tey XS, Desouza K, Toh AH, Mattar NM, Ong KH, Tan J, Tan SC, Kuperan P, Yuen J, Lew E, Heng KML, Tan LK, Koh PL, Lim STT, Khng YL, Bin Mohd Fathil BMF, Ng HP, Lim JL, Wijaya SI and Ang AL

Study On Demographics And Retention of New Donor Pool at Satellite Blood Collection Centers 2013

J.L. Chong, L.H. Poo, D.J. Pennefather

Comparison of the Quality Control Parameters of Buffy Coat Derived Platelets Prepared using Different Pooling Kit

Su Xiaoting, Chua Sze Sze

Malaria Antibody Testing of At-Risk Blood Donors in Singapore

Ramir Alcantara, Aung Nwe Ni, Tan Hwee Huang, Diana Teo

Abstract Title: Lower plasma volume (PV) in Buffy Coat Removed Red Cell may reduce Allergic Transfusion Reaction (ATR): observation in Transfusion Dependent Thalassemia (TDT)

Ang Ai Leen, Shu Pei Huey, Ng Kok Quan

Health Products Regulation Group

Title of Paper


Pharmacogenomic diversity in Singaporean populations and Europeans

Liam R Brunham, Sze-Ling Chan, R Li, F Aminkeng, X Liu, WY Saw, RTH Ong, EN Pillai, Bruce C Carleton, Dorothy Toh, Siew Har Tan, Seok Hwee Koo, Edmund JD Lee, Kee Sing Chia, Colin JD Ross, Michael Hayden, Cynthia Sung and YY Teo

Active surveillance of adverse events following childhood immunization in Singapore.

Koh Cheng Thoon, Sally Bee Leng Soh, Woei Kang Liew, Arunan Gunachandran, Natalie Woon Hui Tan, Chia Yin Chong, Chee Fu Yung.

Investigations into an outbreak of suppurative lymphadenities with BCG vaccine SSI® in Singapore.

Sally Bee Leng Soh, Phey Yen Han, Kai Tong Tam, Chee Fu Yung, Woei Kang Liew, Natalie Woon Hui Tan, Chia Yin Chong, Koh Cheng Thoon.

Traditional Chinese medication for rheumatoid arthritis: more than what meets the eye

Amelia Santosa, Patricia Suet Leng Ng, Gim Gee Teng

Reducing hypersensitivity reactions with HLA-B*5701 genotyping before abacavir prescription:  clinically useful but is it cost-effective in Singapore?

Ritika Kapoor, Rosario Martinez-Vega, Di Dong, Sharlene Yanying Tan, Yee-Sin Leo, Cheng-Chuan Lee, Cynthia Sung, Oon-Tek Ng, Sophia Archuleta, Yik-Ying Teo

Using VigiBase for identifying substandard medicines: detection capacity and key prerequisites.

Kristina Juhlin, Ghazaleh Karimi, Maria Andér, Sara Camilli, Mukesh Dheda, Tan Siew Har, Rokiah Isahak, Su-Jung Lee, Sarah Vaughan, Pia Caduff, G. Niklas Norén

Hepatotoxic potential of asarones: In vitro evaluation of hepatotoxicity and quantitative determination in herbal products

Dhavalkumar Narendrabha Patel, Han Kiat Ho, Libei Liesbet Tan, Mui-Mui Belinda Tan, Qian Zhang, Min-Yong Low, Cheng-Leng Chan and Hwee-Ling Koh.

Intussusception and Monovalent Rotavirus Vaccination in Singapore: Self-Controlled Case Series and Risk-Benefit Study

Chee-Fu Yung, Siew Pang Chan, Sally Soh, Adriana Tan and Koh Cheng Thoon



Research Projects

April 2014 to March 2015

Please click here to download the project details in pdf.

Applied Sciences Group


Principal Investigator(s)

Fully automated analysis of amphetamines, ketamine and its metabolite in urine using disposable pipette extraction tandem mass spectrometry (DPX-LC-MS/MS) 

Moy Hooi Yan, Chang Hian Twan, Jordan Ong Han Hui, Soo Chock Ying, Faridah Salleh, Lui Chi Pang and Yao Yi Ju

Surface-enhanced Raman Spectroscopy (SERS) with colloidal metallic nanoparticles for forensic applications

Ang Thiam Peng

Evaluation of Ultra Fast LC Tandem Mass Spectrometry  against LC Tandem Mass Spectrometry method for Acrylamide Analysis

Lee Lin Min, Yap Wee Kim, Ang Lay Kheng, Peh Hui Zhu

Blood Services Group


Principal Investigator(s)

Validation for HPC-A CD34 enrichment using CliniMACS

Dr Marieta Chan