Antibody-Mediated Pure Red Cell Aplasia (PRCA) case cluster observed with subcutaneous administration of erythropoietin (EPO) Eprex® at a Singapore Institution

Janssen, a division of Johnson & Johnson Pte Ltd (“Janssen”), is informing healthcare professionals of an increase in the number of EPO antibody-mediated PRCA cases with onset in 2012 and 2013 observed from one institution in Singapore. These cases comprise a cluster of 6 Eprex® reports and were reported in patients who had received subcutaneous administration of Eprex® at some point during their treatment. Janssen wishes to reinforce the vigilance for, and identification of, EPO antibody-mediated PRCA and the appropriate storage and handling of Eprex® that is described in the Singapore prescribing information. Please refer to the Dear Healthcare Professional Letter for more details.

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of these letters can be found in the MOH Alert System, which is accessible via the Health Professionals Portal (HPP), a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://hpp.moh.gov.sg and follow the procedures below to access the MOH Alert system.

Step 1: Select your profession under ‘For Healthcare Professionals’.

Step 2: Click on ‘Useful links’.

Step 3: Click on ‘MOH Alert’ and log in via Singpass.

Step 4: Click on ‘Drug Alerts’ or ‘Med Device Alerts’ to view the DHCPLs.