Issue during reconstitution with Actilyse® (alteplase) powder and solvent for solution for injection and infusion

Boehringer Ingelheim International GmbH would like to highlight a recent issue of the rubber stoppers being pushed into the vial during the reconstitution of Actilyse^® Treatment Set 50mg/vial. Over the last months, Boehringer Ingelheim has received an increased number of overseas complaints for Actilyse^® 50 mg describing the rubber stoppers being pushed into the vial during reconstitution. This makes the vial unusable. Healthcare professionals are advised to follow the reconstitution process stated in guidance document enclosed with the letter. Please refer to the letter for details.

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of these letters can be found in the MOH Alert System, which is accessible via the Health Professionals Portal (HPP), a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://hpp.moh.gov.sg ↗ (opens in new tab) and follow the procedures below to access the MOH Alert system.

Step 1: Select your profession under ‘For Healthcare Professionals’.

Step 2: Click on ‘Useful links’.

Step 3: Click on ‘MOH Alert’ and log in via Singpass.

Step 4: Click on ‘Drug Alerts’ or ‘Med Device Alerts’ to view the DHCPLs.