Minurin (desmopressin) 0.1 mg/ml nasal spray, solution: Information about potential risk of arrhythmia and reproductive toxicity from exposure to the excipient chlorobutanol.

A Dear Healthcare Professional Letter has been issued by Ferring Pharmaceuticals to inform healthcare professionals of the potential risk of arrhythmia and reproductive toxicity from exposure to the excipient chlorobutanol that is found in Minurin 0.1 mg/ml nasal spray. Healthcare professionals are advised that Minurin 0.1 mg/ml nasal spray, solution should only be considered in situations when alternative desmopressin formulations are unsuitable for use, and no alternative without chlorobutanol is available in order to avoid potential detrimental effects following exposure to chlorobutanol. Please refer to the letter for details.

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of these letters can be found in the MOH Alert System, which is accessible via the Health Professionals Portal (HPP), a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://hpp.moh.gov.sg and follow the procedures below to access the MOH Alert system.

Step 1: Select your profession under ‘For Healthcare Professionals’.

Step 2: Click on ‘Useful links’.

Step 3: Click on ‘MOH Alert’ and log in via Singpass.

Step 4: Click on ‘Drug Alerts’ or ‘Med Device Alerts’ to view the DHCPLs.