Update of package insert – Iclusig® (ponatinib) and the risks of aneurysms and artery dissections

A Dear Healthcare Professional Letter has been issued by Steward Cross Pte Ltd, informing healthcare professionals of revisions to the package inserts (PI) of Iclusig^® (ponatinib) to include new safety information pertaining to the risks of aneurysms and artery dissections. The new safety information includes a warning that the use of vascular endothelial growth factor (VEGF) pathway inhibitors in patients with or without hypertension may promote the formation of aneurysms and/or artery dissections, and this risk should be carefully considered in patients with risk factors such as hypertension or history of aneurysm before initiation of Iclusig^®. Please refer to the letter for details.

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of these letters can be found in the MOH Alert System, which is accessible via the Health Professionals Portal (HPP), a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://hpp.moh.gov.sg ↗ (opens in new tab) and follow the procedures below to access the MOH Alert system.

Step 1: Select your profession under ‘For Healthcare Professionals’.

Step 2: Click on ‘Useful links’.

Step 3: Click on ‘MOH Alert’ and log in via Singpass.

Step 4: Click on ‘Drug Alerts’ or ‘Med Device Alerts’ to view the DHCPLs.