Update of package insert – New safety information on use of Zoloft (sertraline) in pregnancy

A Dear Healthcare Professional Letter has been issued by Pfizer PFE Pte Ltd to inform healthcare professionals that the package inserts of Zoloft (sertraline) have been updated to include new safety information pertaining to its use in pregnancy. The new safety information includes a statement that observational studies have provided evidence of an increased risk (< 2-fold) of post-partum haemorrhage following exposure to selective serotonin reuptake inhibitors (SSRIs), including sertraline, especially within the month prior to birth. Please refer to the letter for details.

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of these letters can be found in the MOH Alert System, which is accessible via the Health Professionals Portal (HPP), a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://hpp.moh.gov.sg and follow the procedures below to access the MOH Alert system.

Step 1: Select your profession under ‘For Healthcare Professionals’.

Step 2: Click on ‘Useful links’.

Step 3: Click on ‘MOH Alert’ and log in via Singpass.

Step 4: Click on ‘Drug Alerts’ or ‘Med Device Alerts’ to view the DHCPLs.