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Health Sciences Authority
Dear Healthcare Professional Letters

Zelboraf® (Vemurafenib) and the risks of Dupuytren’s Contracture and Plantar Fascial Fibromatosis

Audiences

Healthcare professional

Product type

Therapeutic Products

2 February 2017

This article has been migrated from an earlier version of the site and may display formatting inconsistencies.

Roche would like to inform healthcare professionals that cases of Dupuytren’s contracture and plantar fascial fibromatosis have been reported with Zelboraf® (vemurafenib) use. The reported cases of Dupuytren’s contracture seen with Zelboraf® were characterized by thickening or appearance of visible cords in the palm of one or both hands. In the majority of patients, the event persisted when Zelboraf® treatment was maintained, while symptoms improved or resolved when Zelboraf® was interrupted or discontinued. In addition to Dupuytren’s contracture, rare cases of mild and moderate plantar fascial fibromatosis were also reported. Healthcare professionals are advised to inform patients of these risks and exercise caution in patients with pre-existing Dupuytren’s contracture and plantar fascial fibromatosis and to follow the dose modification guidance for adverse events. Roche is working with HSA to strengthen the product label for Zelboraf®. Please refer to the letter for more details. 


Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of these letters can be found in the MOH Alert System, which is accessible via the Health Professionals Portal (HPP), a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://hpp.moh.gov.sg and follow the procedures below to access the MOH Alert system.

Step 1: Select your profession under ‘For Healthcare Professionals’.

Step 2: Click on ‘Useful links’.

Step 3: Click on ‘MOH Alert’ and log in via Singpass.

Step 4: Click on ‘Drug Alerts’ or ‘Med Device Alerts’ to view the DHCPLs.

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