Educational materials for healthcare professionals

Find educational materials on therapeutic products and cell, tissue or gene therapy products (CTGTP) intended for healthcare professionals or directed at their patients.

Last updated 2 September 2026

Overview

The educational materials listed below highlight specific safety concerns associated with the use of selected therapeutic products and CTGTP, and provide advice on the actions required to optimise the safe and effective use of these products.

Physician Educational Material (PEM): Intended for use by healthcare professionals in conjunction with the approved Singapore package insert. The PEM highlights safety concerns associated with the product and their risk mitigation measures e.g. selection of the appropriate patient group, close adherence to the recommended dosing information, close monitoring for early signs of adverse events that could require therapy modification.
Patient Medication Guide (PMG) and Patient Alert Card (PAC): Intended for dissemination by healthcare professionals to their patients or patients’ caregivers. The PMG and PAC provide important information for patients and their caregivers regarding the use of the product e.g. self-monitoring for early signs and symptoms of adverse events, when to seek prompt medical attention.

Only HSA-approved educational materials are listed below. These materials are published with the agreement of the company responsible for producing them, and are not intended to replace medical advice offered by healthcare professionals.

For electronic package inserts accessed from QR codes printed on the educational materials, there may be a time lag in the publishing of the latest approved package inserts after revisions are approved by HSA. Healthcare professionals should refer to HSA's website for the latest approved package insert for the product.

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Active ingredient(s)	Brand name	Company	Educational material(s)
Ambrisentan	Volibris	GlaxoSmithKline Pte Ltd	Volibris PMG (opens in new tab)
Apixaban	Eliquis	Pfizer Private Limited	Eliquis PAC (opens in new tab)
Apixaban	Apigat	Natco Pharma Asia Pte Ltd	Apigat PAC (opens in new tab)
Apixaban	Hemapix	Sandoz Singapore Pte Ltd	Hemapix PAC Material will be available soon
Atezolizumab	Tecentriq	Roche Singapore Pte Ltd	Tecentriq PMG (opens in new tab)
Avelumab	Bavencio	Merck Pte Ltd	Bavencio PMG (opens in new tab)
Axicabtagene ciloleucel	Yescarta	Gilead Sciences Singapore Pte Ltd	Yescarta PEM Physician (opens in new tab) Yescarta PEM HandlingAdminGuide (opens in new tab) Yescarta PMG (opens in new tab) Yescarta PAC (opens in new tab)
Belantamab mafodotin	Blenrep	GlaxoSmithKline Pte Ltd	Blenrep PEM (opens in new tab) Blenrep PMG (opens in new tab)
Bosentan	Proart	Ranbaxy (Malaysia) Sdn Bhd	Proart PMG (opens in new tab)
Brexucabtagene autoleucel	Tecartus	Gilead Sciences Singapore Pte Ltd	Tecartus PEM Physician (opens in new tab) Tecartus PEM HandlingAdminGuide (opens in new tab) Tecartus PMG (opens in new tab) Tecartus PAC (opens in new tab)
Dabigatran	Pradaxa	Boehringer Ingelheim Singapore Pte Ltd	Pradaxa PAC (opens in new tab)
Dabigatran	Leaxolar	Lotus International Pte Ltd	Leaxolar PAC (opens in new tab)
Daratumumab	Darzalex	Johnson & Johnson International (Singapore) Pte Ltd	Darzalex PEM Physician (opens in new tab) Darzalex PEM Bloodbank (opens in new tab) Darzalex PAC (opens in new tab)
Deferasirox	Jadenu	Novartis (Singapore) Pte Ltd	Jadenu PMG (opens in new tab)
Deferasirox	Deferox	Chemkraft Pte Ltd	Deferox PMG Material will be available soon
Deferasirox	Desroxia	Lotus International Pte Ltd	Desroxia PMG (opens in new tab)
Deferasirox	Ferasiro	Goldplus Universal Pte Ltd	Ferasiro PMG (opens in new tab)
Donanemab	Lormalzi	DKSH Singapore Pte Ltd	Lormalzi PEM (opens in new tab) Lormalzi PAC (opens in new tab)
Dostarlimab	Jemperli	GlaxoSmithKline Pte Ltd	Jemperli PAC (opens in new tab)
Durvalumab	Imfinzi	AstraZeneca Singapore Pte Ltd	Imfinzi PMG (opens in new tab)
Eculizumab	Soliris	AstraZeneca Singapore Pte Ltd	Soliris PEM (opens in new tab) Soliris PMG (opens in new tab) Soliris PAC (opens in new tab)
Edoxaban	Lixiana	A. Menarini Singapore Pte Ltd	Lixiana PAC (opens in new tab)
Elranatamab	Elrexfio	Pfizer Private Limited	Elrexfio PAC (opens in new tab)
Emicizumab	Hemlibra	Roche Singapore Pte Ltd	Hemlibra PMG (opens in new tab) Hemlibra PAC (opens in new tab)
Epcoritamab	Epkinly	Abbvie Pte Ltd	Epkinly PAC (opens in new tab)
Equecabtagene autoleucel	Fucaso	IASO BIO SGP Pte Ltd	Fucaso PEM Handling & Admin (opens in new tab) Fucaso PEM Clinical Safety (opens in new tab) Fucaso PMG (opens in new tab) Fucaso PAC (opens in new tab)
Esketamine	Spravato	Johnson & Johnson International (Singapore) Pte Ltd	Spravato PEM (opens in new tab) Spravato HCP Checklist (opens in new tab) Spravato PMG (opens in new tab)
Etranacogene dezaparvovec	Hemgenix	CSL Behring Pte Ltd	Hemgenix PMG (opens in new tab) Hemgenix PAC (opens in new tab)
Etrasimod	Velsipity	Everest Medicines (Singapore) Pte Ltd	Velsipity PEM (opens in new tab) Velsipity PMG (opens in new tab) Velsipity PAC (opens in new tab)
Fingolimod	Gilenya	Novartis (Singapore) Pte Ltd	Gilenya PEM (opens in new tab) Gilenya PMG (opens in new tab) Gilenya PAC (opens in new tab)
Fingolimod	Fincord	Accord Healthcare Private Limited	Fincord PEM (opens in new tab) Fincord PMG (opens in new tab) Fincord PAC (opens in new tab)
Gilteritinib	Xospata	Astellas Pharma Singapore Pte Ltd	Xospata PAC (opens in new tab)
Glofitamab	Columvi	Roche Singapore Pte Ltd	Columvi PAC (opens in new tab)
Ipilimumab	Yervoy	Bristol-Myers Squibb (Singapore) Pte Ltd	Yervoy PAC (opens in new tab)
Iptacopan	Fabhalta	Novartis (Singapore) Pte Ltd	Fabhalta PEM (opens in new tab) Fabhalta PMG (opens in new tab) Fabhalta PAC (opens in new tab)
Isatuximab	Sarclisa	Sanofi-aventis Singapore Pte Ltd	Sarclisa PEM (opens in new tab) Sarclisa PAC (opens in new tab)
Ivosidenib	Tibsovo	Servier (S) Pte Ltd	Tibsovo PAC (opens in new tab)
Lecanemab	Leqembi	Eisai (Singapore) Pte Ltd	Leqembi PEM (opens in new tab) Leqembi PAC (opens in new tab)
Lenalidomide	Revlimid	Bristol-Myers Squibb (Singapore) Pte Ltd	Revlimid PEM (opens in new tab) Revlimid PMG (opens in new tab)
Lenalidomide	Leavdo	Pharm-D Singapore Private Limited	Leavdo PEM (opens in new tab) Leavdo PMG (opens in new tab)
Lenalidomide	Lenalidomide Grindeks	Goldplus Universal Pte Ltd	Lenalidomide Grindeks PEM (opens in new tab) Lenalidomide Grindeks PMG (opens in new tab)
Lenalidomide	Lenalidomide-Teva	Teva Pharmaceutical Investments Singapore Pte Ltd	Lenalidomide-Teva PEM (opens in new tab) Lenalidomide-Teva PMG (opens in new tab)
Lenalidomide	Lenangio	Zyfas Pharma Pte Ltd	Lenangio PEM (opens in new tab) Lenangio PMG (opens in new tab)
Lenalidomide	Lenli	Lotus International Pte Ltd	Lenli PEM (opens in new tab) Lenli PMG (opens in new tab)
Lenalidomide	Linadex	Hetero Singapore Pte Ltd	Linadex PEM (opens in new tab) Linadex PMG (opens in new tab)
Lenalidomide	Myolid	DKSH Singapore Pte Ltd	Myolid PEM (opens in new tab) Myolid PMG (opens in new tab)
Leuprorelin	Eligard	DCH Auriga Singapore	Eligard PEM (opens in new tab)
Macitentan	Opsumit	Johnson & Johnson International (Singapore) Pte Ltd	Opsumit PAC (opens in new tab)
Macitentan, Tadalafil	Opsynvi	Johnson & Johnson International (Singapore) Pte Ltd	Opsynvi PAC (opens in new tab)
Mavacamten	Camzyos	Bristol-Myers Squibb (Singapore) Pte Ltd	Camzyos PEM (opens in new tab) Camzyos PMG (opens in new tab) Camzyos PAC (opens in new tab)
Mosunetuzumab	Lunsumio	Roche Singapore Pte Ltd	Lunsumio PAC (opens in new tab)
Natalizumab	Tysabri	Eisai (Singapore) Pte Ltd	Tysabri PEM (opens in new tab) Tysabri PAC (opens in new tab)
Nivolumab	Opdivo	Bristol-Myers Squibb (Singapore) Pte Ltd	Opdivo PAC (opens in new tab)
Nivolumab, Relatlimab	Opdualag	Bristol-Myers Squibb (Singapore) Pte Ltd	Opdualag PAC (opens in new tab)
Onasemnogene abeparvovec	Zolgensma	Novartis (Singapore) Pte Ltd	Zolgensma PMG (opens in new tab)
Pembrolizumab	Keytruda	MSD Pharma (Singapore) Pte Ltd	Keytruda PMG (opens in new tab)
Pomalidomide	Pomalyst	Bristol-Myers Squibb (Singapore) Pte Ltd	Pomalyst PEM (opens in new tab) Pomalyst PMG (opens in new tab)
Pomalidomide	Pomagen	Lotus International Pte Ltd	Pomagen PEM (opens in new tab) Pomagen PMG (opens in new tab)
Ravulizumab	Ultomiris	AstraZeneca Singapore Pte Ltd	Ultomiris PEM (opens in new tab) Ultomiris PMG (opens in new tab) Ultomiris PAC (opens in new tab)
Rivaroxaban	Xarelto	Bayer (South East Asia) Pte Ltd	Xarelto Tablet PAC (opens in new tab) Xarelto Suspension PAC (opens in new tab)
Rivaroxaban	Estaelto	Wellesta Healthcare (Singapore) Pte Ltd	Estaelto PAC (opens in new tab)
Rivaroxaban	Invarox	Intega Pte Ltd	Invarox PAC (opens in new tab)
Rivaroxaban	Ixobran	Goldplus Universal Pte Ltd	Ixobran PAC Material will be available soon
Rivaroxaban	Jbrivo	United Italian Trading Corporation (Private) Limited	Jbrivo PAC (opens in new tab)
Rivaroxaban	Oranxa	Ranbaxy (Malaysia) Sdn Bhd	Oranxa PAC Material will be available soon
Rivaroxaban	Rivaroxaban-Teva	Teva Pharmaceutical Investments Singapore Pte Ltd	Rivaroxaban-Teva PAC (opens in new tab)
Rivaroxaban	Rivason	Alma-A Pte Ltd	Rivason PAC (opens in new tab)
Rivaroxaban	Rivoban	Chemkraft Pte Ltd	Rivoban PAC (opens in new tab)
Rivaroxaban	Xabarem	Goldplus Universal Pte Ltd	Xabarem PAC (opens in new tab)
Rivaroxaban	Xafariv	Viatris Private Limited	Xafariv PAC (opens in new tab)
Rivaroxaban	Xarid	Zyfas Pharma Pte Ltd	Xarid PAC Material will be available soon
Rivaroxaban	Zyroxaban	Apex Pharma Marketing Pte Ltd	Zyroxaban PAC (opens in new tab)
Serplulimab	Zerpidio	Innogene Kalbiotech Pte Ltd	Zerpidio PMG (opens in new tab)
Siponimod	Mayzent	Novartis (Singapore) Pte Ltd	Mayzent PEM (opens in new tab) Mayzent PMG (opens in new tab) Mayzent PAC (opens in new tab)
Spheroids of human autologous matrix-associated chondrocytes	SpheChon	ReLive Biotechnologies Pte Ltd	SpheChon PMG (opens in new tab)
Tagraxofusp	Elzonris	A. Menarini Singapore Pte Ltd	Elzonris PAC (opens in new tab)
Talquetamab	Talvey	Johnson & Johnson International (Singapore) Pte Ltd	Talvey PAC (opens in new tab)
Tarlatamab	Imdelltra	Amgen Biotechnology Singapore Pte Ltd	Imdelltra PAC (opens in new tab)
Teclistamab	Tecvayli	Johnson & Johnson International (Singapore) Pte Ltd	Tecvayli PAC (opens in new tab)
Teprotumumab	Tepezza	Amgen Biotechnology Singapore Pte Ltd	Tepezza PEM (opens in new tab) Tepezza PMG (opens in new tab)
Thalidomide	Domide	Pharm-D Singapore Private Limited	Domide PEM (opens in new tab) Domide PMG (opens in new tab)
Tisagenlecleucel	Kymriah	Novartis (Singapore) Pte Ltd	Kymriah PEM Physician (opens in new tab) Kymriah PEM PharmLabInf (opens in new tab) Kymriah PMG (opens in new tab) Kymriah PAC (opens in new tab)
Tislelizumab	Tevimbra	BeOne Medicines Singapore Pte Ltd	Tevimbra PAC (opens in new tab)
Tolvaptan	Jinarc	Otsuka Pharmaceuticals (Singapore) Pte Ltd	Jinarc PMG (opens in new tab)
Toripalimab	Loqtorzi	TA Biosciences Pte Ltd	Loqtorzi PMG (opens in new tab)
Tremelimumab	Imjudo	AstraZeneca Singapore Pte Ltd	Imjudo PMG (opens in new tab)
Voretigene neparvovec	Luxturna	Novartis (Singapore) Pte Ltd	Luxturna PEM Surgical Manual (opens in new tab) Luxturna PEM Pharmacy Manual (opens in new tab) Luxturna PMG (opens in new tab) Luxturna PAC (opens in new tab) Note: Audio version of the PMG and PAC are available online. Please refer to the educational materials for the weblink.