Increased risk of serious bleeding in patients with unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI) when Effient is administered prior to diagnostic coronary angiography

Eli Lily and Company would like to inform healthcare professionals of new recommendation on the administration of Effient (prasugrel) in patients undergoing percutaneous coronary intervention (PCI). In UA/NSTEMI patients, when coronary angiography is performed within 48 hours after admission, the loading dose of Effient should only be given at the time of PCI in order to minimize the risk of bleeding. This is based on the outcome of a recently completed clinical study in NSTEMI patients. The use of an initial loading dose prior to coronary angiography followed by an additional dose at the time of PCI is associated with an increased risk of bleeding, as compared with a single prasugrel loading dose at the time of PCI. The package inserts of Effient have been updated to capture this new safety information. Please refer to the letter for more details.