MOTILIUM (Domperidone) Oral Suspension (1mg/mL) and Tablet (10mg): Changes to dosage recommendations

A Dear Healthcare Professional Letter has been issued by Janssen to update healthcare professionals on the recent changes to the dosage recommendations of MOTILIUM (Domperidone) oral suspension (1mg/mL) and tablet (10mg) to minimize cardiac risks including serious arrhythmia and sudden cardiac death associated with the use of the medicine.  A higher risk was observed in patients older than 60 years, and in patients taking daily doses of more than 30mg/day. Healthcare professionals are advised to prescribe MOTILIUM at the lowest effective dose for the shortest possible duration and stop its treatment if signs or symptoms occur that may be associated with cardiac arrhythmia. Healthcare professionals are advised to refer to the letter for details.

 
 
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.moh.gov.sg/hpp/, and follow the procedures below to access the MOH Alert system.

Step 1: On the top navigation ribbon of webpage, select 'For Healthcare Professionals' followed by 'Health Professionals Portal' and click on the choice of profession. User will be redirected to the specific HPP webpage for the selected profession.

Step 2: Click on the Restricted Content icon on the left panel of webpage and login via SingPass.

Step 3: Click on the MOH Alert icon under ‘Applications’ section

Step 4: Click on the Drug Alert tab to view the DHCPLs.