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Monitoring the safety profile of COVID-19 vaccines

HSA has issued a Dear Healthcare Professional Letter (DHCPL) to highlight to healthcare professionals the requirements on the safety monitoring of COVID-19 vaccine(s) that has been authorised for use in Singapore. As the COVID-19 vaccination programme is progressively rolled out, healthcare professionals are advised to remind vaccine recipients to monitor any adverse events (AEs) that may occur with COVID-19 vaccine(s) and to report all suspected serious adverse events (SAEs) to HSA:

  • all fatal and life-threatening events should be reported within 24 hours (Note: Fatal events are reportable as Coroner’s cases under the Coroners Act)
  • all other SAEs and Adverse Events of Special Interest (AESIs) are to be reported as soon as possible and within 48 hours

Healthcare professionals are also required to notify the National Immunisation Registry as soon as possible, within 48 hours, of all persons who have been vaccinated with the COVID-19 vaccine(s) through the respective IT systems. HSA will continue to monitor the safety profile of COVID-19 vaccine(s) and communicate any relevant updates to healthcare professionals.

Please refer to the letter for details.

Healthcare professional, Industry member, Therapeutic Products

Dear Healthcare Professional Letters

30 Dec 2020

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at, and follow the procedures below to access the MOH Alert system.

Step 1: On the top navigation ribbon of webpage, select 'For Healthcare Professionals' followed by 'Health Professionals Portal' and click on the choice of profession. User will be redirected to the specific HPP webpage for the selected profession.

Step 2: Click on the Restricted Content icon on the left panel of webpage and login via SingPass.

Step 3: Click on the MOH Alert icon under ‘Applications’ section

Step 4: Click on the Drug Alert tab to view the DHCPLs.