Skip to main content
A Singapore Government Agency Website

Update of package insert – New safety information on use of Zoloft (sertraline) in pregnancy

A Dear Healthcare Professional Letter has been issued by Pfizer PFE Pte Ltd to inform healthcare professionals that the package inserts of Zoloft (sertraline) have been updated to include new safety information pertaining to its use in pregnancy. The new safety information includes a statement that observational studies have provided evidence of an increased risk (< 2-fold) of post-partum haemorrhage following exposure to selective serotonin reuptake inhibitors (SSRIs), including sertraline, especially within the month prior to birth. Please refer to the letter for details.
Healthcare professional, Industry member, Therapeutic Products

Dear Healthcare Professional Letters

8 Jul 2021

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at, and follow the procedures below to access the MOH Alert system.

Step 1: On the top navigation ribbon of webpage, select 'For Healthcare Professionals' followed by 'Health Professionals Portal' and click on the choice of profession. User will be redirected to the specific HPP webpage for the selected profession.

Step 2: Click on the Restricted Content icon on the left panel of webpage and login via SingPass.

Step 3: Click on the MOH Alert icon under ‘Applications’ section

Step 4: Click on the Drug Alert tab to view the DHCPLs.