Educational materials for healthcare professionals

Find educational materials on therapeutic products and cell, tissue or gene therapy products (CTGTP) intended for healthcare professionals or directed at their patients

Overview

The educational materials listed below highlight specific safety concerns associated with the use of selected therapeutic products and CTGTP, and provide advice on the actions required to optimise the safe and effective use of these products.

  • Physician Educational Material (PEM): Intended for use by healthcare professionals in conjunction with the approved Singapore package insert. The PEM highlights safety concerns associated with the product and their risk mitigation measures e.g. selection of the appropriate patient group, close adherence to the recommended dosing information, close monitoring for early signs of adverse events that could require therapy modification.
  • Patient Medication Guide (PMG) and Patient Alert Card (PAC): Intended for dissemination by healthcare professionals to their patients or patients’ caregivers. The PMG and PAC provide important information for patients and their caregivers regarding the use of the product e.g. self-monitoring for early signs and symptoms of adverse events, when to seek prompt medical attention.

Only HSA-approved educational materials are listed below. These materials are published with the agreement of the company responsible for producing them, and are not intended to replace medical advice offered by healthcare professionals.

For electronic package inserts accessed from QR codes printed on the educational materials, there may be a time lag in the publishing of the latest approved package inserts after revisions are approved by HSA. Healthcare professionals should refer to HSA's website for the latest approved package insert for the product.

Active ingredient(s)Brand nameCompanyEducational material(s)
AlemtuzumabLemtradaSanofi-aventis Singapore Pte Ltd

Lemtrada PEM1299 KB

Lemtrada PMG1129 KB

Lemtrada PAC2252 KB

AmbrisentanVolibrisGlaxoSmithKline Pte LtdVolibris PMG3103 KB
ApixabanEliquisPfizer Private LimitedEliquis PAC1231 KB
AtezolizumabTecentriqRoche Singapore Pte LtdTecentriq PMG1650 KB
AvelumabBavencioMerck Pte LtdBavencio PMG184 KB
Axicabtagene ciloleucelYescartaGilead Sciences Singapore Pte Ltd

Yescarta PEM Physician1996 KB

Yescarta PEM HandlingAdminGuide247 KB

Yescarta PMG1023 KB

Yescarta PAC118 KB

Belantamab mafodotinBlenrep GlaxoSmithKline Pte Ltd

Blenrep PEM Physician3855 KB

Blenrep PEM Eye Care Evaluation Guide 609 KB

Blenrep PMG2591 KB 

Belimumab BenlystaGlaxoSmithKline Pte LtdBenlysta PMG352 KB
Bosentan
 
TracleerJohnson & Johnson International (Singapore) Pte Ltd

Tracleer PMG148 KB

BosentanProart Ranbaxy (Malaysia) Sdn BhdProart PMG415 KB
Brexucabtagene autoleucelTecartusGilead Sciences Singapore Pte Ltd 
Tecartus PEM

Tecartus PMG

Tecartus PAC

Materials will be available soon


CYD Dengue Virus Serotype 1-4DengvaxiaSanofi-aventis Singapore Pte Ltd

Dengvaxia PEM83 KB

Dengvaxia PMG62 KB

DabigatranPradaxaBoehringer Ingelheim Singapore Pte LtdPradaxa PAC1501 KB
DaratumumabDarzalexJohnson & Johnson International (Singapore) Pte Ltd

Darzalex PEM Physician582 KB

Darzalex PEM Bloodbank715 KB

Darzalex PAC75 KB

DeferasiroxJadenuNovartis (Singapore) Pte Ltd

Jadenu PMG958 KB

DostarlimabJemperliGlaxoSmithKline Pte LtdJemperli PAC151 KB 
DurvalumabImfinziAstraZeneca Singapore Pte LtdImfinzi PMG125 KB
Eculizumab SolirisAstraZeneca Singapore Pte Ltd

Soliris PEM

Soliris PMG

Soliris PAC

EdoxabanLixianaA. Menarini Singapore Pte LtdLixiana PAC1448 KB
EmicizumabHemlibraRoche Singapore Pte Ltd

Hemlibra PMG96 KB

Hemlibra PAC75 KB

EsketamineSpravatoJohnson & Johnson International (Singapore) Pte Ltd

Spravato PEM1144 KB

Spravato HCP Checklist108 KB

Spravato PMG2399 KB

 EtrasimodVelsipity
Everest Medicines (Singapore) Pte Ltd
Velsipity PEM

Velsipity PMG

Velsipity PAC

 FingolimodGilenyaNovartis (Singapore) Pte Ltd

Gilenya PEM563 KB

Gilenya PMG1790 KB

Gilenya PAC155 KB

FingolimodFincordAccord Healthcare Private Limited

Fincord PEM203 KB

Fincord PMG165 KB

Fincord PAC141 KB

GilteritinibXospataAstellas Pharma Singapore Pte LtdXospata PAC249 KB
GlofitamabColumviRoche Singapore Pte LtdColumvi PAC52 KB             
IpilimumabYervoyBristol-Myers Squibb (Singapore) Pte LtdYervoy PMG1410 KB
Isatuximab Sarclisa Sanofi-aventis Singapore Pte Ltd

Sarclisa PEM6625 KB

Sarclisa PAC3101 KB 

LenalidomideRevlimidBristol-Myers Squibb (Singapore) Pte Ltd
Revlimid PEM134 KB

Revlimid PMG106 KB 
Lenalidomide Lenalidomide-TevaTeva Pharmaceutical Investments Singapore Pte Ltd 

Lenalidomide-Teva PEM122 KB

Lenalidomide-Teva PMG160 KB

LenalidomideLenangioZyfas Medical Co 

Lenangio PEM1441 KB

Lenangio PMG1423 KB

LenalidomideLenli Lotus International Pte Ltd

Lenli PEM1564 KB

Lenli PMG1345 KB

LenalidomideLinadex Hetero Singapore Pte Ltd

Linadex PEM1373 KB

Linadex PMG1366 KB

LenalidomideMyolidDKSH Singapore Pte Ltd

Myolid PEM

Myolid PMG

LeuprorelinEligardDCH Auriga SingaporeEligard PEM
MacitentanOpsumitJohnson & Johnson International (Singapore) Pte LtdOpsumit PMG104 KB
MavacamtenCamzyosBristol-Myers Squibb (Singapore) Pte Ltd

Camzyos PEM449 KB

Camzyos PMG163 KB

Camzyos PAC69 KB

Mosunetuzumab

Lunsumio

Roche Singapore Pte Ltd

Lunsumio PAC63 KB

NatalizumabTysabriEisai (Singapore) Pte Ltd

Tysabri PEM549 KB

Tysabri PAC93 KB

NivolumabOpdivoBristol-Myers Squibb (Singapore) Pte LtdOpdivo PMG1328 KB
Nivolumab, RelatlimabOpdualagBristol-Myers Squibb (Singapore) Pte Ltd

Opdualag PAC380 KB

Onasemnogene abeparvovecZolgensmaNovartis (Singapore) Pte Ltd

Zolgensma PMG383 KB

OzanimodZeposiaBristol-Myers Squibb (Singapore) Pte Ltd

Zeposia PEM112 KB

Zeposia PMG198 KB
 

Zeposia PAC71 KB

PembrolizumabKeytrudaMSD Pharma (Singapore) Pte LtdKeytruda PMG1515 KB
PomalidomidePomalystBristol-Myers Squibb (Singapore) Pte Ltd
Pomalyst PEM134 KB

Pomalyst PMG106 KB 
PomalidomidePomagen Lotus International Pte LtdPomagen PEM301 KB

Pomagen PMG207 KB
RavulizumabUltomiris
AstraZeneca Singapore Pte LtdUltomiris PEM165 KB

Ultomiris PMG168 KB

Ultomiris PAC318 KB
RivaroxabanXareltoBayer (South East Asia) Pte Ltd

Xarelto Tablet PAC714 KB

Xarelto Suspension PAC3156 KB
RivaroxabanInvaroxIntega Pte Ltd

Invarox PAC1640 KB

SiponimodMayzentNovartis (Singapore) Pte Ltd

Mayzent PEM

Mayzent PMG567 KB

Mayzent PAC

Spheroids of human autologous matrix-associated chondrocytesSpheChonLabcorp Development (Asia) Pte Ltd

SpheChon PMG184 KB

TagraxofuspElzonrisA. Menarini Singapore Pte LtdElzonris PAC 
Teclistamab

Tecvayli

Johnson & Johnson International (Singapore) Pte Ltd

Tecvayli PAC50 KB

ThalidomideDomidePharm-D Singapore Private Limited

Domide PEM

Domide PMG

TisagenlecleucelKymriahNovartis (Singapore) Pte Ltd

Kymriah PEM Physician777 KB

Kymriah PEM PharmLabInf

Kymriah PMG162 KB

Kymriah PAC458 KB

TolvaptanJinarc Otsuka Pharmaceuticals (Singapore) Pte LtdJinarc PMG1590 KB
TremelimumabImjudoAstraZeneca Singapore Pte Ltd

Imjudo PMG202 KB

 
Voretigene neparvovecLuxturnaNovartis (Singapore) Pte Ltd

Luxturna PEM Surgical Manual1463 KB

Luxturna PEM Pharmacy Manual731 KB

Luxturna PMG497 KB

Luxturna PAC489 KB

Note: Audio version of the PMG and PAC are available online. Please refer to the educational materials for the weblink.